Rangaswamy Madhavi, Porjesz Bernice, Chorlian David B, Wang Kongming, Jones Kevin A, Bauer Lance O, Rohrbaugh John, O'Connor Sean J, Kuperman Samuel, Reich Theodore, Begleiter Henri
Department of Psychiatry, State University of New York, SUNY Health Sciences Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY, USA.
Biol Psychiatry. 2002 Oct 15;52(8):831-42. doi: 10.1016/s0006-3223(02)01362-8.
In this study, the magnitude and spatial distribution of beta power in the resting electroencephalogram (EEG) were examined to address the possibility of an excitation-inhibition imbalance in the central nervous system of alcoholics.
Log transformed absolute power in the Beta 1 (12.5-16 Hz), Beta 2 (16.5-20 Hz), and Beta 3 (20.5-28 Hz) bands in the eyes-closed EEG of 307 alcohol-dependent subjects and 307 unaffected age- and gender-matched control subjects were compared using a multivariate repeated measures design. Effect of gender, age, and drinking variables was examined separately.
Increased Beta 1 (12.5-16 Hz) and Beta 2 (16.5-20 Hz) absolute power was observed in alcohol-dependent subjects at all loci over the scalp. The increase was most prominent in the central region. Increased Beta 3 (20.5-28 Hz) power was frontal in the alcoholics. Age and clinical variables did not influence the increase. Male alcoholics had significantly higher beta power in all three bands. In female alcoholics the increase did not reach statistical significance.
Beta power in all three bands of resting EEG is elevated in alcoholics. This feature is more prominent in male alcoholics. The increased beta power in the resting EEG may be an electrophysiological index of the imbalance in the excitation-inhibition homeostasis in the cortex.
在本研究中，检测静息脑电图（EEG）中β波功率的大小和空间分布，以探讨酒精依赖者中枢神经系统兴奋-抑制失衡的可能性。
采用多变量重复测量设计，比较307名酒精依赖者和307名年龄、性别匹配的未受影响对照者闭眼EEG中β1（12.5 - 16Hz）、β2（16.5 - 20Hz）和β3（20.5 - 28Hz）频段经对数转换后的绝对功率。分别检测性别、年龄和饮酒变量的影响。
在酒精依赖者头皮的所有位点，均观察到β1（12.5 - 16Hz）和β2（16.5 - 20Hz）绝对功率增加。这种增加在中央区域最为显著。酒精依赖者的β3（20.5 - 28Hz）功率增加主要在额叶。年龄和临床变量不影响这种增加。男性酒精依赖者在所有三个频段的β波功率均显著更高。女性酒精依赖者的增加未达到统计学显著性。
酒精依赖者静息EEG的所有三个频段的β波功率均升高。这一特征在男性酒精依赖者中更为突出。静息EEG中β波功率增加可能是皮质兴奋-抑制稳态失衡的电生理指标。
