Mendes Paulo Fernando Santos, Baia-da-Silva Daiane Claydes, Melo Wallacy Watson Pereira, Bittencourt Leonardo Oliveira, Souza-Rodrigues Renata Duarte, Fernandes Luanna Melo Pereira, Maia Cristiane do Socorro Ferraz, Lima Rafael Rodrigues
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Department of Morphology and Physiological Sciences, Center of Sciences Biological and Health, State University of Pará, Belém, Brazil.
Front Pharmacol. 2023 Aug 1;14:1209616. doi: 10.3389/fphar.2023.1209616. eCollection 2023.
Alcohol consumption is common in many societies and has increased considerably, resulting in many socioeconomic and public health problems. In this sense, studies have been carried out in order to understand the mechanisms involved in alcohol consumption and related harmful effects. This study aimed to identify and map the knowledge and to perform bibliometric analysis of the neurotoxicology of alcohol based on the 100 most cited articles. A search was carried out in the Web of Science Core Collection database and information was extracted regarding the journal, authors, keywords, year of publication, number of citations, country and continent of the corresponding author. For each selected manuscript, the study design, alcohol exposure model, dose, period of exposure, and effect on the central nervous system and research hotspots were mapped. The journal with the highest number of publications was Alcoholism: Clinical and Experimental Research (n = 11 papers), the author who contributed the most was Crews FT (n = 8 papers), the studies had a total of 288 keywords and 75% of the publications were from the United States of America. The experimental studies evaluated the effects of prenatal and postnatal exposure and were conducted in rats and mice using doses ranging from 2.5 to 14 g/kg/day, with administration by subcutaneous, intraperitoneal, intragastric, or inhalation route or with free access through drinking bottles. Among the studies mapped, the oldest one (1989) aimed to understand the systemic damage and mechanisms of action involved, while the most recent focused on understanding the receptors and mechanisms involved in addiction, as well as genetic factors. Our results show the panorama of the most widespread scientific production in the scientific community on the neurotoxicology of ethanol, a high prevalence was observed in studies that addressed fetal alcohol syndrome and/or the effects of ethanol on neurodevelopment.
饮酒在许多社会中都很常见，且有显著增加，导致了诸多社会经济和公共卫生问题。从这个意义上说，人们开展了多项研究，以了解饮酒及其相关有害影响所涉及的机制。本研究旨在识别和梳理关于酒精神经毒理学的知识，并基于被引频次最高的100篇文章进行文献计量分析。我们在科学网核心合集数据库中进行了检索，并提取了有关期刊、作者、关键词、出版年份、被引次数、通讯作者所在国家和大洲的信息。对于每一篇选定的手稿，我们梳理了研究设计、酒精暴露模型、剂量、暴露时间以及对中枢神经系统的影响和研究热点。发表文章数量最多的期刊是《酒精中毒：临床与实验研究》（11篇论文），贡献最大的作者是克鲁斯·FT（8篇论文），这些研究共有288个关键词，75%的出版物来自美国。实验研究评估了产前和产后暴露的影响，在大鼠和小鼠中进行，使用的剂量范围为2.5至14克/千克/天，给药途径包括皮下、腹腔内、胃内或吸入途径，或通过饮水瓶自由摄取。在梳理的研究中，最早的一项（1989年）旨在了解所涉及的全身损害和作用机制，而最新的研究则侧重于了解成瘾所涉及的受体和机制以及遗传因素。我们的结果展示了科学界关于乙醇神经毒理学最广泛的科学生产全景，在涉及胎儿酒精综合征和/或乙醇对神经发育影响的研究中观察到了高患病率。
