Rathi Bharti, Azad Rajeek K, Vasudha N, Hissaria Praveen, Sawlani Vijay, Gupta Rakesh K
Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Pediatr Neurosurg. 2002 Oct;37(4):203-5. doi: 10.1159/000065395.
Reversible posterior leukoencephalopathy syndrome (RPLS) is being increasingly described with various etiologies even in the absence of hypertension. We present an 11-year-old patient with acute lymphoblastic leukemia who presented with seizures while on treatment with L-asparaginase. MRI showed bilaterally symmetrical nonenhancing occipital lesions characteristic of RPLS. L-Asparaginase-induced RPLS is a rare cause of neurological symptoms in patients on induction chemotherapy.
可逆性后部白质脑病综合征（RPLS）的病因日益多样，甚至在无高血压的情况下也有相关报道。我们报告一名11岁急性淋巴细胞白血病患者，在接受L-天冬酰胺酶治疗时出现癫痫发作。磁共振成像（MRI）显示双侧对称的枕叶病变，具有RPLS的特征。L-天冬酰胺酶诱导的RPLS是诱导化疗患者出现神经症状的罕见原因。
