麦角酰胺诱发的伴有癫痫持续状态的后部可逆性脑病综合征。
Lysergic acid amide-induced posterior reversible encephalopathy syndrome with status epilepticus.
作者信息
Legriel Stephane, Bruneel Fabrice, Spreux-Varoquaux Odile, Birenbaum Aurelie, Chadenat Marie Laure, Mignon François, Abbosh Nathalie, Henry-Lagarrigue Matthieu, Revault D'Allonnes Laure, Guezennec Pierre, Troche Gilles, Bedos Jean Pierre
机构信息
Service de Réanimation Polyvalente, Hôpital André Mignot, 78157, Le Chesnay, France.
出版信息
Neurocrit Care. 2008;9(2):247-52. doi: 10.1007/s12028-008-9096-5.
INTRODUCTION
Posterior reversible encephalopathy syndrome (PRES) is known to occur in association with several substances. However, lysergic acid amide (LSA) is not among the previously reported causes of PRES.
METHODS
We report on a patient with PRES presenting as convulsive status epilepticus associated with hypertensive encephalopathy after LSA ingestion. Magnetic resonance imaging was performed and catecholamine metabolites assayed.
RESULTS
The patient achieved a full recovery after aggressive antihypertensive therapy and intravenous anticonvulsivant therapy. The clinical history, blood and urinary catecholamine levels, and response to treatment strongly suggest that PRES was induced by LSA.
CONCLUSION
LSA, a hallucinogenic agent chiefly used for recreational purposes, should be added to the list of causes of PRES.
引言
已知后可逆性脑病综合征（PRES）与多种物质有关。然而，麦角酰胺（LSA）并非先前报道的PRES病因之一。
方法
我们报告了一名在摄入LSA后出现与高血压脑病相关的惊厥性癫痫持续状态的PRES患者。进行了磁共振成像检查并测定了儿茶酚胺代谢产物。
结果
患者在积极的抗高血压治疗和静脉注射抗惊厥治疗后完全康复。临床病史、血液和尿液中的儿茶酚胺水平以及对治疗的反应强烈提示PRES是由LSA诱发的。
结论
LSA是一种主要用于娱乐目的的致幻剂，应添加到PRES的病因列表中。
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