Armanini D, Fiore C, Mattarello M J, Bielenberg J, Palermo M
Department of Medical and Surgical Sciences -Endocrinology University of Padua, Italy.
Exp Clin Endocrinol Diabetes. 2002 Sep;110(6):257-61. doi: 10.1055/s-2002-34587.
The history of licorice as an officinal plant dates back thousands of years, and licorice is still appreciated as a medicinal root. Many of its endocrine properties can be derived from observations of Authors of the ancient world, when hormones were not known. Inappropriate use of licorice can produce pseudoaldosteronism, by inactivating 11beta-hydroxysteroiod-dehydrogenase and by binding to mineralocorticoid receptors. Licorice possesses many other therapeutic properties as to potentiate the action of cortisol, to reduce testosterone synthesis, especially in women, to exert an estrogen-like activity and to reduce body fat mass. The chronological development of research on these effects is described.
甘草作为一种药用植物的历史可以追溯到数千年前，并且甘草至今仍被视为一种药根。它的许多内分泌特性可以从古代作者的观察中推导出来，当时人们还不知道激素。不当使用甘草会通过使11β-羟基类固醇脱氢酶失活以及与盐皮质激素受体结合而产生假性醛固酮增多症。甘草还具有许多其他治疗特性，如增强皮质醇的作用、减少睾酮合成（尤其是在女性中）、发挥类似雌激素的活性以及减少体脂量。本文描述了对这些作用的研究的时间发展过程。
