Meurman Jukka H, Rantonen Panu, Pajukoski Hanna, Sulkava Raimo
Institute of Dentistry, University of Helsinki, Finland.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Oct;94(4):432-8. doi: 10.1067/moe.2002.122345.
Our objective was to study salivary albumin concentrations in the elderly. We expected higher albumin values in the frail and diseased elderly in comparison to the more fit elderly. This was thought to be due to the eventually decreased mucosal integrity in the diseased patients.
Paraffin wax-stimulated saliva was collected for 5 minutes from 131 hospitalized elderly, mean age of 82 years, and 252 elderly outpatients, mean age of 77 years. Forty-seven of the hospitalized elderly died during the 2-year follow-up. Albumin was analyzed spectrophotometrically from the saliva specimens, and values were studied statistically between the groups and regarding a number of background variables.
The following mean salivary albumin concentrations were observed: outpatients, 200 +/- 157 microg/mL; hospitalized surviving patients, 401 +/- 247 microg/mL; patients who later died, 501 +/- 417 microg/mL. The respective albumin output values were 439.7 +/- 432.8 microg/min in outpatients, 684.3 +/- 396.8 microg/min in hospitalized patients who survived, and 700.0 +/- 481.9 microg/min in the hospitalized patients who died. The differences were significant between the groups. The strongest explanatory factors for higher than median albumin concentrations were the use of analgesics in the hospitalized patients (odds ratio, 4.2; confidence interval, 1.5 to 11.4) and retaining own teeth in the outpatients (odds ratio, 4.3; confidence interval, 1.9 to 4.3). Frequency of mucosal pathologic condition did not appear as an explanatory factor in this respect.
Our study hypothesis was confirmed, showing significantly higher salivary albumin concentrations in the frail elderly. The present results may also be used as reference data for salivary albumin in the elderly.
我们的目的是研究老年人唾液白蛋白浓度。我们预计，与身体状况较好的老年人相比，身体虚弱和患病的老年人白蛋白值更高。这被认为是由于患病患者黏膜完整性最终下降所致。
从131名平均年龄82岁的住院老年人和252名平均年龄77岁的老年门诊患者中，收集石蜡刺激唾液5分钟。131名住院老年人中有47人在2年随访期间死亡。用分光光度法分析唾液标本中的白蛋白，并对组间以及一些背景变量进行统计学研究。
观察到以下唾液白蛋白平均浓度：门诊患者为200±157微克/毫升；住院存活患者为401±247微克/毫升；后来死亡的患者为501±417微克/毫升。门诊患者、住院存活患者和住院死亡患者各自的白蛋白输出值分别为439.7±432.8微克/分钟、684.3±396.8微克/分钟和700.0±481.9微克/分钟。组间差异显著。白蛋白浓度高于中位数的最强解释因素是住院患者使用镇痛药（比值比，4.2；置信区间，1.5至11.4）以及门诊患者保留自己的牙齿（比值比，4.3；置信区间，1.9至4.3）。在这方面，黏膜病理状况的频率未表现为解释因素。
我们的研究假设得到证实，表明身体虚弱的老年人唾液白蛋白浓度显著更高。目前的结果也可作为老年人唾液白蛋白的参考数据。
