Seo Dae Yun, Hwang Boo Geun
Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea.
Department of Sport Rehabilitation, Tong Myong University, Busan, Republic of Korea.
Phys Act Nutr. 2020 Sep;24(3):32-38. doi: 10.20463/pan.2020.0019. Epub 2020 Sep 30.
Sarcopenia is considered one of the major causes of disability in the elderly population and is highly associated with aging. Exercise is an essential strategy for improving muscle health while aging and involves multiple metabolic and transcriptional adaptations. Although the beneficial effects of exercise modalities on skeletal muscle structure and function in aging are well recognized, the exact cellular and molecular mechanisms underlying the influence of exercise have not been fully elucidated.
We summarize the biochemical pathways involved in the progression and pathogenesis of sarcopenia and describe the beneficial effects of exercise training on the relevant signaling pathways associated with sarcopenia.
This study briefly introduces current knowledge on the signaling pathways involved in the development of sarcopenia, effects of aerobic exercise on mitochondria-related parameters and mitochondrial function, and role of resistance exercise in the regulation of muscle protein synthesis against sarcopenia.
This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia.
肌肉减少症被认为是老年人群残疾的主要原因之一，且与衰老高度相关。运动是衰老过程中改善肌肉健康的重要策略，涉及多种代谢和转录适应性变化。尽管运动方式对衰老骨骼肌结构和功能的有益作用已得到充分认识，但运动影响的确切细胞和分子机制尚未完全阐明。
我们总结了肌肉减少症进展和发病机制中涉及的生化途径，并描述了运动训练对与肌肉减少症相关的信号通路的有益作用。
本研究简要介绍了目前关于肌肉减少症发生发展所涉及的信号通路、有氧运动对线粒体相关参数和线粒体功能的影响以及抗阻运动在调节肌肉蛋白质合成以对抗肌肉减少症中的作用的知识。
本综述表明运动的有益作用仍未得到充分研究，加快研究将有助于开发更好的方法来预防、管理和治疗肌肉减少症。
