通过原位杂交检测人结直肠癌中的爱泼斯坦-巴尔病毒
Detection of Epstein-Barr virus in human colorectal cancer by in situ hybridazition.
作者信息
Liu Huan-Xin, Ding Yan-Qing, Sun Ya-Ou, Liang Li, Yang Yu-Fang, Qi Zong-Li, Liu Ji-Hong, Xiong Ping-Xia
机构信息
Department of Pathology, First Military Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2002 Oct;22(10):915-7.
OBJECTIVE
To investigate the relationship between Epstein-Barr virus (EBV) and the pathogenesis of human colorectal cancer.
METHODS
The small-molecule RNA fragments of EBV was examined by in situ hybridization in colorectal cancer specimens obtained from 130 patients.
RESULTS
EBV was found in the 6 of 130 colorectal cancer cases. EBV positivity was more prevalent in male patients (4/6), and the tumor tissues of the 4 EBV-positive cases were featured by obvious stromal infiltration by the lymphocytes (4/6).
CONCLUSION
EBV infection might be related to the pathogenesis of some colorectal adenocarcinomas in China, and intensive lymphocyte infiltration in the stroma of the tumor tissues can be an important pathological indication of EBV infection in colorectal tumors.
目的
探讨爱泼斯坦-巴尔病毒（EBV）与人类结直肠癌发病机制之间的关系。
方法
采用原位杂交技术检测130例结直肠癌患者标本中EBV的小分子RNA片段。
结果
130例结直肠癌病例中有6例检测到EBV。EBV阳性在男性患者中更为常见（4/6），4例EBV阳性病例的肿瘤组织表现为淋巴细胞明显浸润间质（4/6）。
结论
EBV感染可能与中国部分结直肠癌的发病机制有关，肿瘤组织间质中密集的淋巴细胞浸润可能是结直肠癌中EBV感染的重要病理指征。
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