Lankisch P G, Assmus C, Maisonneuve P, Lowenfels A B
Department of Internal Medicine, Municipal Clinic of Lüneburg, Germany.
Pancreatology. 2002;2(5):469-77. doi: 10.1159/000064713.
BACKGROUND/AIMS: Worldwide, the incidence of pancreatic cancer is very well known, that of acute pancreatitis and chronic pancreatitis not. Our study sought to determine the incidence of all three pancreatic diseases in a well-defined population in Germany.
Records of all patients treated for acute (first attacks only) and chronic pancreatitis as well as pancreatic cancer from 1988 to 1995 and who resided in the county of Lüneburg were evaluated.
The crude incidence rates for acute pancreatitis, chronic pancreatitis and pancreatic cancer per 100,000 inhabitants/year were 19.7, 6.4, and 7.8. In acute and chronic pancreatitis the male gender dominated, whereas in pancreatic carcinoma the gender ratio was almost even. Peak incidence for acute pancreatitis was in the age group of 35-44 years, for chronic pancreatitis 45-54, and for pancreatic cancer 65-75. Etiology of acute pancreatitis was biliary in 40%, alcohol abuse in 32%, unknown in 20%, and other in 8% of the patients. In chronic pancreatitis alcohol abuse was the etiology in 72% and unknown (idiopathic) in 28%.
For the first time, epidemiological data obtained in a well-defined German population are being published relating to all three pancreatic diseases: acute pancreatitis (incidence rate, etiology and severity), chronic pancreatitis (incidence rate and etiology), and pancreatic carcinoma (incidence rate). A peak incidence of chronic pancreatitis occurring in an age group 10 years older than the peak age group for acute pancreatitis suggests that chronic pancreatitis develops during this time-frame following first attacks of acute pancreatitis.
背景/目的：在全球范围内，胰腺癌的发病率广为人知，而急性胰腺炎和慢性胰腺炎的发病率却并非如此。我们的研究旨在确定德国一个明确界定的人群中这三种胰腺疾病的发病率。
对1988年至1995年期间居住在吕讷堡县、因急性（仅首次发作）和慢性胰腺炎以及胰腺癌接受治疗的所有患者的记录进行评估。
每10万居民/年的急性胰腺炎、慢性胰腺炎和胰腺癌的粗发病率分别为19.7、6.4和7.8。在急性和慢性胰腺炎中男性占主导，而在胰腺癌中性别比例几乎相等。急性胰腺炎的发病高峰年龄在35 - 44岁组，慢性胰腺炎在45 - 54岁组，胰腺癌在65 - 75岁组。急性胰腺炎的病因中，40%为胆源性，32%为酒精滥用，20%病因不明，8%为其他原因。在慢性胰腺炎中，72%的病因是酒精滥用，28%病因不明（特发性）。
首次公布了在德国一个明确界定的人群中获得的关于所有三种胰腺疾病的流行病学数据：急性胰腺炎（发病率、病因和严重程度）、慢性胰腺炎（发病率和病因）以及胰腺癌（发病率）。慢性胰腺炎的发病高峰年龄比急性胰腺炎的发病高峰年龄组大10岁，这表明慢性胰腺炎是在急性胰腺炎首次发作后的这段时间内发展而来的。
