Arts W F, Oosterhuis H J
Neurology. 1975 Nov;25(11):1088-90. doi: 10.1212/wnl.25.11.1088.
The working capacity of inbred female Swiss mice on the rotating rod was tested in an investigation of the effect of previously injected prednisolone, 1.2 mg, on the neuromuscular blocking effect of two different doses of d-tubocurarine and of low-dose hemicholinium-3. The effect of both drugs could be partially or wholly antagonized by prednisolone. The consequences of this finding are discussed in relation to the beneficial effect of prednisone in patients with myasthenia gravis.
在一项研究中，对预先注射1.2毫克泼尼松龙后近交系雌性瑞士小鼠在转棒上的工作能力进行了测试，该研究旨在探讨预先注射的泼尼松龙对两种不同剂量的d-筒箭毒碱和低剂量的3-羟甲基氯化物神经肌肉阻滞作用的影响。两种药物的作用均可被泼尼松龙部分或完全拮抗。结合泼尼松对重症肌无力患者的有益作用，对这一发现的后果进行了讨论。
