Buresová M, Hanzlíková V, Gutmann E
Pflugers Arch. 1975 Oct 28;360(2):95-108. doi: 10.1007/BF00580533.
The ribosomal capacity for protein synthesis in the fast extensor digitorum longus muscle of the rat is markedly higher than in the slow soleus muscle. Implantation of the "fast" peroneal nerve into the denervated or into the self-reinnervated soleus muscle results in transformation (increase) of capacity of isolated ribosomes for protein synthesis into that of the fast muscle type. The degree of transformation is higher after implantation into the self-reinnervated than into the denervated soleus muscle. A high degree of recovery of weight and tetanic tension output is recorded after the "fast" nerve implantation. The effect of transformation with respect to contraction properties is considerably more marked in the case of heteroinnervation of the denervated muscle and persists even after 5 months of heteroinnervation. Transformation of the histochemical muscle fibre pattern is also more pronounced after heteroinnervation of the denervated than self-reinnervated soleus muscle; the muscle acquires the fibre pattern of the fast extensor digitorum longus muscle. The acquisition of the reciprocal pattern of oxidative and glycolytic enzymes suggests that the activation of protein synthesis induced by the foreign "fast" nerve supply is coupled with the operation of specific RNA species.
大鼠趾长伸肌（快肌）中核糖体进行蛋白质合成的能力显著高于比目鱼肌（慢肌）。将“快”的腓神经植入去神经支配或自身重新神经支配的比目鱼肌，会使分离核糖体进行蛋白质合成的能力转变（增加）为快肌类型。植入自身重新神经支配的比目鱼肌后的转变程度高于植入去神经支配的比目鱼肌。“快”神经植入后，肌肉重量和强直张力输出有高度恢复。在去神经支配肌肉的异种神经支配情况下，收缩特性的转变效应更为显著，甚至在异种神经支配5个月后依然存在。去神经支配的比目鱼肌异种神经支配后，组织化学肌纤维模式的转变也比自身重新神经支配更为明显；该肌肉获得了趾长伸肌的纤维模式。氧化酶和糖酵解酶相互模式的获得表明，外来“快”神经供应诱导的蛋白质合成激活与特定RNA种类的运作相关联。
