白细胞介素15和白细胞介素18在炎症反应中的作用。
Role of interleukin 15 and interleukin 18 in inflammatory response.
作者信息
Liew F Y, McInnes I B
机构信息
Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, UK.
出版信息
Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii100-2. doi: 10.1136/ard.61.suppl_2.ii100.
Abstract
Interleukin 15 (IL15) and interleukin 18 (IL18) are cytokines produced principally by macrophages during innate immune response and subsequently profoundly influence adaptive immunity. Recent studies have shown that IL15 and IL18 play an influential part in inflammatory response. Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis.
摘要
白细胞介素15（IL15）和白细胞介素18（IL18）是在天然免疫应答过程中主要由巨噬细胞产生的细胞因子，随后对适应性免疫产生深远影响。最近的研究表明，IL15和IL18在炎症反应中发挥着重要作用。在此，我们主要展示来自我们自己实验室的最新数据，这些数据阐明了IL15和IL18在实验性和临床类风湿性滑膜炎的慢性炎症诱导及持续过程中的重要性。
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