Lepargneur J P, Rousseau V
Laboratoire des Carmes, CEDIBIO, 9, avenue Etienne-Billières, 31000 Toulouse, France.
J Gynecol Obstet Biol Reprod (Paris). 2002 Sep;31(5):485-94.
The vaginal flora of a healthy woman is composed of the Doderleïn bacilli (different species of lactobacilli) forming a biofilm on the mucosa. These bacteria have a beneficial effect by inhibiting growth, adhesion or spread of other microorganisms. Different mechanisms are recognized, including secretion of organic acids, production of antimicrobial substances (hydrogen peroxide, bacteriocins and biosurfactants), competition for nutrients (arginine deiminase), competition for receptors (adhesion on the epithelium), steric exclusion (biosurfactants, adhesion on the epithelium or on the fibronectin) and co-aggregation. This ecological balance can be disturbed by drugs (antibiotics and spermicides) or by local devices. A new therapeutic approach has been proposed to restore a normal flora: the use of probiotics by the association of different lactobacilli with combined antimicrobial activity.
健康女性的阴道菌群由多德勒林杆菌（不同种类的乳酸杆菌）组成，这些杆菌在黏膜上形成生物膜。这些细菌通过抑制其他微生物的生长、黏附或扩散而产生有益作用。人们认识到了不同的机制，包括有机酸的分泌、抗菌物质（过氧化氢、细菌素和生物表面活性剂）的产生、对营养物质的竞争（精氨酸脱亚氨酶）、对受体的竞争（上皮细胞上的黏附）、空间排斥（生物表面活性剂、上皮细胞或纤连蛋白上的黏附）以及共聚集。这种生态平衡可能会受到药物（抗生素和杀精剂）或局部装置的干扰。已经提出了一种新的治疗方法来恢复正常菌群：通过将具有联合抗菌活性的不同乳酸杆菌联合使用益生菌。
