Ahmadfakhrodin Mahak, Ghalati Sahar Yousefi, Mazinani Sara, HekmatiPour Nafiseh, Mazalzadeh Fakhriyeh, Ghiasi Nasrin
Department of Pharmacutial, Doctor of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
J Family Med Prim Care. 2024 Oct;13(10):4159-4164. doi: 10.4103/jfmpc.jfmpc_1387_23. Epub 2024 Oct 18.
The evaluation of adverse effects caused by poly-pharmacy (PHP) in patients, especially in the elderly group, is very important. The purpose of the present study was to evaluate the prevalence and factors affecting PHP in elderly patients. This study was conducted as a narrative review. Related articles were downloaded using reliable international databases and specialized mesh terms. Finally, the results of 29 articles were extracted based on the authors' names, study location, sample size, and key results. The findings of the study showed that the prevalence of PHP in the elderly was higher after discharge from the hospital than during hospitalization. In addition, the prevalence of PHP in the elderly who lived in care centers was higher than in those who lived at home. Based on the findings, there was a relationship between the source of obtaining information about drugs and the pattern of PHP consumption. The findings of the present study showed that PHP leads to serious complications in the elderly. Based on the results of the study, it can be concluded that some variables such as age, sex, health level, financial status, place of residence, type of disease, number of simultaneous diseases, hospitalization, duration of hospitalization, level of awareness of the elderly and their caregivers, the care place of elderly, and the number of visits of the elderly to the physician can be effective in the prevalence of PHP. Strategies such as choosing treatment goals for each patient in preventing unnecessary drug use, identifying at-risk groups, and periodically monitoring the benefits and side effects of drugs can be effective in reducing drug complications caused by PHP in the elderly.
评估多重用药（PHP）对患者，尤其是老年患者造成的不良反应非常重要。本研究的目的是评估老年患者中PHP的患病率及影响因素。本研究以叙述性综述的形式开展。使用可靠的国际数据库和专业医学主题词下载相关文章。最后，根据作者姓名、研究地点、样本量和关键结果提取了29篇文章的结果。研究结果表明，老年患者出院后的PHP患病率高于住院期间。此外，住在护理中心的老年患者的PHP患病率高于居家患者。基于这些发现，获取药物信息的来源与PHP的用药模式之间存在关联。本研究结果表明，PHP会导致老年患者出现严重并发症。根据研究结果可以得出结论，年龄、性别、健康水平、经济状况、居住地点、疾病类型、同时患有的疾病数量、住院情况、住院时长、老年人及其照顾者的认知水平、老年人的护理场所、老年人看医生的次数等一些变量可能会对PHP的患病率产生影响。在预防不必要的药物使用方面，为每位患者选择治疗目标、识别高危人群以及定期监测药物的益处和副作用等策略，可能有助于减少PHP在老年患者中引起的药物并发症。
