对来自意大利医院的鲍曼不动杆菌流行病学无关临床分离株中整合子的分子特征分析显示，基因盒阵列的多样性有限。
Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian hospitals reveals a limited diversity of gene cassette arrays.
作者信息
Gombac Francesca, Riccio Maria Letizia, Rossolini Gian Maria, Lagatolla Cristina, Tonin Enrico, Monti-Bragadin Carlo, Lavenia Annamaria, Dolzani Lucilla
机构信息
Dipartimento di Scienze Biomediche, Sezione di Microbiologia, Università di Trieste, I-34127 Trieste, Italy.
出版信息
Antimicrob Agents Chemother. 2002 Nov;46(11):3665-8. doi: 10.1128/AAC.46.11.3665-3668.2002.
Abstract
Integron carriage by 36 epidemiologically unrelated Acinetobacter baumannii isolates collected over an 11-year period from patients in six different Italian hospitals was investigated. Sixteen type 1 integron-positive isolates (44%) were found, 13 of which carried the same array of cassettes, i.e., aacC1, orfX, orfX', and aadA1a. As ribotype analysis of the isolates demonstrated a notable genetic diversity, horizontal transfer of the entire integron structure or ancient acquisition was hypothesized.
摘要
对11年间从意大利6家不同医院的患者中收集的36株流行病学上不相关的鲍曼不动杆菌分离株携带整合子的情况进行了调查。发现16株（44%）1型整合子阳性分离株，其中13株携带相同的盒式结构阵列，即aacC1、orfX、orfX'和aadA1a。由于对这些分离株的核糖体分型分析显示出显著的遗传多样性，因此推测整个整合子结构发生了水平转移或为古老获得。
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