异丙肾上腺素和普萘洛尔对大鼠心肌鸟氨酸脱羧酶的影响。
The effect of isoprenaline and propranolol on rat myocardial ornithine decarboxylase.
作者信息
Warnica J W, Antony P, Gibson K, Harris P
出版信息
Cardiovasc Res. 1975 Nov;9(6):793-6. doi: 10.1093/cvr/9.6.793.
PMID:1239331
Abstract
The intraperitoneal injection of isoprenaline in rats caused an increase in myocardial ornithine decarboxylase activity which reached a maximum of about four times the control value one hour after the injection. The intraperitoneal injection of dl-propranolol had no effect on myocardial ornithine decarboxylase activity. The injection of dl-propranolol 30 min before the injection of isoprenaline almost completely prevented the effect of isoprenaline.
摘要
给大鼠腹腔注射异丙肾上腺素会导致心肌鸟氨酸脱羧酶活性增加，注射后1小时该活性达到最大值，约为对照值的四倍。腹腔注射dl-普萘洛尔对心肌鸟氨酸脱羧酶活性没有影响。在注射异丙肾上腺素前30分钟注射dl-普萘洛尔几乎完全抑制了异丙肾上腺素的作用。
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