在灌注大鼠心脏中“原位”评估钙离子在异丙肾上腺素激活鸟氨酸脱羧酶过程中的作用。
Involvement of calcium ions in the activation of ornithine decarboxylase by isoprenaline evaluated 'in situ' in the perfused rat heart.
作者信息
Guarnieri C, Flamigni F, Muscari C, Caldarera C M
出版信息
Biochem J. 1983 Apr 15;212(1):241-3. doi: 10.1042/bj2120241.
Abstract
Ornithine decarboxylase activity evaluated during the perfusion of isolated rat hearts by a method 'in situ' was rapidly increased when the hearts were infused with isoprenaline (isoproterenol). Omission of Ca2+ from the perfusion medium or the administration of verapamil to the perfused hearts decreased the isoprenaline-stimulated ornithine decarboxylase activity, whereas a marked stimulatory effect was registered when the hearts were perfused with the Ca2+ ionophore A23187.
摘要
通过“原位”方法在离体大鼠心脏灌注过程中评估的鸟氨酸脱羧酶活性，在心脏用异丙肾上腺素灌注时迅速增加。灌注介质中去除Ca2+或向灌注的心脏给予维拉帕米可降低异丙肾上腺素刺激的鸟氨酸脱羧酶活性，而当心脏用Ca2+离子载体A23187灌注时则出现明显的刺激作用。
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