Rettig G, Gibson K, Harris P
Res Commun Chem Pathol Pharmacol. 1977 Sep;18(1):67-74.
Ornithine decarboxylase activity was higher in the left ventricle than in the right ventricle of the rat. Swimming exercise for 2 hours caused an increase in left ventricular but not right ventricular enzyme activity. This effect was not influenced by the prior injection of propranolol, which also had no influence on the resting level of ornithine decarboxylase activity. After 4 hours' exposure to 400 mm Hg the decarboxylase activity became greater in the right ventricle. This was attributed to the increased work-load on the right ventricle caused by hypoxic pulmonary hypertension. In the left ventricle, ornithine decarboxylase showed an initial increase in activity followed by a transient decrease at 16 hours. Propranolol had no effect on the changes observed in either ventricle. It is concluded that beta-receptor stimulation is not involved in the mechanism of an increased myocardial ornithine decarboxylase activity during increased cardiac work.
鸟氨酸脱羧酶活性在大鼠左心室中高于右心室。持续2小时的游泳运动导致左心室酶活性增加，但右心室酶活性未增加。这种效应不受预先注射普萘洛尔的影响，普萘洛尔对鸟氨酸脱羧酶的静息活性水平也没有影响。在暴露于400毫米汞柱4小时后，右心室的脱羧酶活性增强。这归因于缺氧性肺动脉高压导致右心室工作负荷增加。在左心室中，鸟氨酸脱羧酶活性最初增加，随后在16小时出现短暂下降。普萘洛尔对两个心室中观察到的变化均无影响。得出的结论是，心脏工作增加期间心肌鸟氨酸脱羧酶活性增加的机制不涉及β受体刺激。
