Al-Shahi R, Fang J S Y, Lewis S C, Warlow C P
Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):547-51. doi: 10.1136/jnnp.73.5.547.
To conduct a population based study of brain arteriovenous malformation (AVM) prevalence.
Multiple, overlapping sources of case ascertainment were used to establish the point prevalence of brain AVMs in the adult population of the Lothian health board of Scotland. Patients were sought retrospectively from all local general (family) practitioners, neurologists, neurosurgeons, stroke physicians, the specialist AVM clinic at the regional neuroscience centre, and routine coding of hospital discharge data. Case notes, brain imaging, and pathology reports were reviewed to validate each patient's diagnosis and to ensure that each was alive, over the age of 16 years, and resident in the geographical area of the study on the prevalence date of 30 June 1998.
Of 148 potentially eligible people, 93 adults met the inclusion criteria. There were 40 women and 53 men. Men were significantly younger than women on the prevalence date (median age 39 years v 51 years, p = 0.003). Of those included, 25 (27%) had radiological evidence of prior therapeutic obliteration of their brain AVM and 9 (10%) had coexisting aneurysms. The minimum crude brain AVM prevalence was 15 per 100 000 adults and capture-recapture analysis gave an ascertainment adjusted prevalence of 18 (95% confidence interval 16 to 24) per 100 000 adults.
The minimum estimate of brain AVM prevalence helps to assess its burden and comparative epidemiology and stresses the importance of brain AVMs as a cause of long term disability in adults.
开展一项基于人群的脑动静脉畸形（AVM）患病率研究。
利用多种重叠的病例确诊来源，确定苏格兰洛锡安健康委员会成年人群中脑AVM的点患病率。通过回顾性研究，从当地所有全科（家庭）医生、神经科医生、神经外科医生、中风科医生、地区神经科学中心的AVM专科诊所，以及医院出院数据的常规编码中查找患者。查阅病例记录、脑部影像和病理报告，以验证每位患者的诊断，并确保其在1998年6月30日患病率调查日期时存活、年龄超过16岁且居住在研究地理区域内。
在148名可能符合条件的人中，93名成年人符合纳入标准。其中有40名女性和53名男性。在患病率调查日期时，男性的年龄显著低于女性（中位年龄39岁对51岁，p = 0.003）。在纳入的患者中，25例（27%）有脑部AVM既往治疗性闭塞的影像学证据，9例（10%）有并存动脉瘤。脑AVM的最低粗患病率为每10万名成年人中有15例，捕获-再捕获分析得出经确诊调整后的患病率为每10万名成年人中有18例（95%置信区间16至24）。
脑AVM患病率的最低估计值有助于评估其负担和比较流行病学，并强调脑AVM作为成年人长期残疾原因的重要性。
