Church James M
Section of Endoscopy, Department of Colorectal Surgery, Cleveland Clinic, Ohio 44195, USA.
Gastrointest Endosc. 2002 Nov;56(5):672-4. doi: 10.1067/mge.2002.128916.
Colonic spasm can interfere with colonoscopy by hindering insertion of the colonoscope and by making polypectomy difficult, painful, and dangerous. Methods for dealing with colonic spasm include waiting for it to subside and administration of antispasmodic agents such as glucagon or hyoscyamine. Glucagon is expensive and hyoscyamine has side effects. This study evaluated an inexpensive technique, warm water irrigation, for overcoming colonic spasm during colonoscopy.
A prospective, randomized, controlled trial in a consecutive series of patients was conducted to compare warm water irrigation for relaxation of spasm with standard examination techniques. Patients in whom the sigmoid colon had been resected were excluded. In the test group, water from the hot water tap at approximately body temperature was instilled into the colon by means of the accessory channel of the colonoscope with a 30 mL syringe. Any irrigation, either for removal of stool or control of spasm, was performed with warm water in the test group and water at room temperature in the control group. After each colonoscopy, the level of pain experienced by the patient was recorded with a linear analog scale.
Sixty-nine patients were randomized. The groups were similar with respect to gender distribution, age, and degree of spasm. There was no difference between groups for insertion time, total duration of colonoscopy, dose of midazolam administered, or frequency of severe spasm. Patients who had warm water irrigation had significantly less discomfort than control patients (median 2.0, interquartile range: 1-4 on a 10 point linear analog scale, vs. 4.0, interquartile range: 2-5).
Although glucagon and hyoscyamine remain options for treatment of colonic spasm, the results of this study suggest that warm water is also effective. It has no side effects and costs practically nothing.
结肠痉挛会妨碍结肠镜插入,使息肉切除困难、痛苦且危险,进而干扰结肠镜检查。处理结肠痉挛的方法包括等待其缓解以及使用抗痉挛药物,如胰高血糖素或莨菪碱。胰高血糖素价格昂贵,莨菪碱有副作用。本研究评估了一种廉价技术——温水灌注,用于在结肠镜检查期间克服结肠痉挛。
对一系列连续患者进行前瞻性、随机、对照试验,比较温水灌注缓解痉挛与标准检查技术。排除乙状结肠已切除的患者。在试验组中,通过带有30 mL注射器的结肠镜附件通道将接近体温的热水龙头中的水注入结肠。在试验组中,任何用于清除粪便或控制痉挛的灌注均使用温水,对照组使用室温的水。每次结肠镜检查后,用线性模拟量表记录患者的疼痛程度。
69例患者被随机分组。两组在性别分布、年龄和痉挛程度方面相似。在插入时间、结肠镜检查总时长、咪达唑仑给药剂量或严重痉挛频率方面,两组之间没有差异。接受温水灌注的患者比对照组患者的不适明显更少(在10分线性模拟量表上,中位数为2.0,四分位间距:1 - 4,而对照组为4.0,四分位间距:2 - 5)。
尽管胰高血糖素和莨菪碱仍是治疗结肠痉挛的选择,但本研究结果表明温水也有效。它没有副作用且几乎没有成本。