Morgan T, Davis J M
Pflugers Arch. 1975 Aug 29;359(1-2):23-31. doi: 10.1007/BF00581275.
Blood was collected from the descending aorta, from a renal efferent arteriole and from the renal vein of a rat. The renin concentrations of the blood samples were measured. The renal vein renin concentration was 673 +/- 81 (SE) ng ml-1h-1 which was significantly higher than the concentration in the aorta of 456 +/- 50 (SE) ng ml-1h-1. The concentration of renin in the renal efferent arteriole was significantly lower than that in the aorta. These observations imply that net renin secretion is a combination of two processes; removal between artery and efferent arteriole and entry between efferent arteriole and renal vein. It appears that renin is released into the interstitium and enters the circulation at the capillary level rather than being released into the afferent or efferent arterioles. This mode of secretion supports the suggestion that the renin angiotensin system may primarily work intra-renally rather than through the systemic circulation.
从大鼠的降主动脉、肾出球小动脉和肾静脉采集血液。测量血样中的肾素浓度。肾静脉肾素浓度为673±81（标准误）ng ml-1h-1，显著高于主动脉中的浓度456±50（标准误）ng ml-1h-1。肾出球小动脉中的肾素浓度显著低于主动脉中的浓度。这些观察结果表明，肾素的净分泌是两个过程的组合；在动脉和出球小动脉之间的清除以及在出球小动脉和肾静脉之间的进入。肾素似乎释放到间质中，并在毛细血管水平进入循环，而不是释放到入球或出球小动脉中。这种分泌方式支持了肾素-血管紧张素系统可能主要在肾内起作用而不是通过体循环起作用的观点。
