Tscheng Dorothy Z
Drug Information and Research Centre, Ontario Pharmacists' Association, Don Mills, Ontario, Canada.
Ann Pharmacother. 2002 Nov;36(11):1785-90. doi: 10.1345/aph.1C019.
To review the efficacy and safety of various drug treatments for sialorrhea. Pharmacotherapy for drug-induced sialorrhea is not addressed.
Clinical studies were identified using PubMed (1966-October 2001). Key search terms included sialorrhea and drug therapy.
Sialorrhea is a social and physical detriment to patients. Drug treatment, although not necessarily the treatment of choice for all patients, can offer some symptom relief.
Literature has documented that benztropine, glycopyrrolate, and scopolamine can reduce the incidence of sialorrhea. Although the literature evaluating the therapeutic options has limitations (e.g., small sample size, inconsistent outcome measurements), glycopyrrolate may have an advantage over the other agents due to fewer adverse effects.
回顾各种药物治疗流涎症的疗效和安全性。本文不涉及药物性流涎症的药物治疗。
通过PubMed（1966年至2001年10月）检索临床研究。主要检索词包括流涎症和药物治疗。
流涎症对患者的社交和身体都有损害。药物治疗虽然不一定是所有患者的首选治疗方法，但可以缓解一些症状。
文献记载苯海索、格隆溴铵和东莨菪碱可降低流涎症的发生率。尽管评估这些治疗选择的文献存在局限性（如样本量小、结局测量不一致），但格隆溴铵可能因其不良反应较少而优于其他药物。
