Oliveira Roselaine P, Velasco Irineu, Soriano Francisco Garcia, Friedman Gilberto
Department of Critical Care Medicine, Santa Casa Hospital, Federal University of Rio Grande do Sul, Porto Alegra, Brazil.
Crit Care. 2002 Oct;6(5):418-23. doi: 10.1186/cc1541. Epub 2002 Aug 6.
The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. Specific actions of hypertonic saline in severe sepsis and septic shock are highlighted. Data are available that support potential benefits of hypertonic saline infusion in various aspects of the pathophysiology of sepsis, including tissue hypoperfusion, decreased oxygen consumption, endothelial dysfunction, cardiac depression, and the presence of a broad array of proinflammatory cytokines and various oxidant species. The goal of research in this field is to identify reliable therapies to prevent ischemia and inflammation, and to reduce mortality.
本综述讨论了高渗盐水在实验性休克和脓毒症患者中的血流动力学效应。我们依据出血性休克和脓毒性休克的数据，对高渗盐水的作用机制进行了评论。重点介绍了高渗盐水在严重脓毒症和脓毒性休克中的具体作用。现有数据支持高渗盐水输注在脓毒症病理生理学的各个方面可能带来的益处，包括组织灌注不足、氧消耗减少、内皮功能障碍、心脏抑制以及存在多种促炎细胞因子和各种氧化物质。该领域的研究目标是确定可靠的疗法，以预防缺血和炎症，并降低死亡率。
