Ulutin H Cüneyt, Arpaci Fikret, Pak Yücel
Department of Radiation Oncology, Gülhane Military Medicine Academy, Faculty of Medicine, Ankara, Turkey.
Tumori. 2002 Jul-Aug;88(4):277-80. doi: 10.1177/030089160208800406.
The primary aim of the study was to compare two different dose levels of megestrol acetate, administered for cancer-related anorexia and cachexia for 3 months.
From August 1996 to December 2000, 119 patients with advanced non-small cell lung cancer were randomized to take 160 mg/day or 320 mg/day of megestrol acetate for 3 months at the Gülhane Military Medicine Academy of Ankara, Turkey. Patients were controlled at biweekly periods.
There were 59 patients in the single dose arm (group 1) and 60 patients in the twice a day dose arm (group 2). The mean percentages of weight loss were 16.9% and 16.7% in group 1 and 2, respectively. In the first and the second month of weight gain, there were no significant differences in the two groups (P = 0.23 and P = 0.11). In the third month, weight gain was significantly higher in group 2 than in group 1 (P = 0.038). Toxicity was similar for both dose levels.
Megestrol acetate can be safely and effectively given to patients with advanced non-small cell lung cancer. Although lower doses of megestrol acetate can be effective for anorexia and cachexia, the higher dose level seems to be more efficient.
本研究的主要目的是比较醋酸甲地孕酮两种不同剂量水平用于癌症相关性厌食和恶病质3个月的效果。
1996年8月至2000年12月，在土耳其安卡拉的古尔汗军事医学院，119例晚期非小细胞肺癌患者被随机分为两组，分别服用160毫克/天或320毫克/天的醋酸甲地孕酮，为期3个月。每两周对患者进行一次检查。
单剂量组（第1组）有59例患者，每日两次剂量组（第2组）有60例患者。第1组和第2组体重减轻的平均百分比分别为16.9%和16.7%。在体重增加的第一个月和第二个月，两组之间无显著差异（P = 0.23和P = 0.11）。在第三个月，第2组的体重增加显著高于第1组（P = 0.038）。两种剂量水平的毒性相似。
醋酸甲地孕酮可安全有效地用于晚期非小细胞肺癌患者。虽然较低剂量的醋酸甲地孕酮对厌食和恶病质可能有效，但较高剂量水平似乎更有效。
