Cremesti Aida E, Goni Felix M, Kolesnick Richard
Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, 430 East 67th Street, New York, NY 10021, USA.
FEBS Lett. 2002 Oct 30;531(1):47-53. doi: 10.1016/s0014-5793(02)03489-0.
Recent biophysical data suggest that the properties of ceramide observed in model membranes may apply to biological systems. In particular, the ability of ceramide to form microdomains, which coalesce into larger platforms or macrodomains, appears to be important for some cellular signaling processes. Several laboratories have now demonstrated similar reorganization of plasma membrane sphingolipid rafts, via ceramide generation, into macrodomains. This event appeared necessary for signaling upon activation of a specific set of cell surface receptors. In this article, we review the properties and functions of rafts, and the role of sphingomyelinase and ceramide in the biogenesis and re-modeling of these rafts. As clustering of some cell surface receptors in these domains may be critical for signal transduction, we propose a new model for transmembrane signal transmission.
最近的生物物理数据表明，在模型膜中观察到的神经酰胺特性可能适用于生物系统。特别是，神经酰胺形成微结构域并聚集成更大的平台或大结构域的能力，对于某些细胞信号传导过程似乎很重要。现在有几个实验室已经证明，通过神经酰胺的产生，质膜鞘脂筏会发生类似的重组，形成大结构域。这一事件似乎是激活一组特定细胞表面受体后进行信号传导所必需的。在本文中，我们综述了筏的特性和功能，以及鞘磷脂酶和神经酰胺在这些筏的生物发生和重塑中的作用。由于这些结构域中某些细胞表面受体的聚集可能对信号转导至关重要，我们提出了一种跨膜信号传递的新模型。
