Clancy Luke, Goodman Pat, Sinclair Hamish, Dockery Douglas W
St James' Hospital, Dublin, Ireland.
Lancet. 2002 Oct 19;360(9341):1210-4. doi: 10.1016/S0140-6736(02)11281-5.
Particulate air pollution episodes have been associated with increased daily death. However, there is little direct evidence that diminished particulate air pollution concentrations would lead to reductions in death rates. We assessed the effect of air pollution controls--ie, the ban on coal sales--on particulate air pollution and death rates in Dublin.
Concentrations of air pollution and directly-standardised non-trauma, respiratory, and cardiovascular death rates were compared for 72 months before and after the ban of coal sales in Dublin. The effect of the ban on age-standardised death rates was estimated with an interrupted time-series analysis, adjusting for weather, respiratory epidemics, and death rates in the rest of Ireland.
Average black smoke concentrations in Dublin declined by 35.6 mg/m(3) (70%) after the ban on coal sales. Adjusted non-trauma death rates decreased by 5.7% (95% CI 4-7, p<0.0001), respiratory deaths by 15.5% (12-19, p<0.0001), and cardiovascular deaths by 10.3% (8-13, p<0.0001). Respiratory and cardiovascular standardised death rates fell coincident with the ban on coal sales. About 116 fewer respiratory deaths and 243 fewer cardiovascular deaths were seen per year in Dublin after the ban.
Reductions in respiratory and cardiovascular death rates in Dublin suggest that control of particulate air pollution could substantially diminish daily death. The net benefit of the reduced death rate was greater than predicted from results of previous time-series studies.
空气污染事件与每日死亡人数增加有关。然而,几乎没有直接证据表明颗粒物空气污染浓度降低会导致死亡率下降。我们评估了空气污染控制措施(即煤炭销售禁令)对都柏林颗粒物空气污染和死亡率的影响。
比较了都柏林煤炭销售禁令前后72个月的空气污染浓度以及直接标准化的非创伤性、呼吸道和心血管疾病死亡率。通过中断时间序列分析估计了禁令对年龄标准化死亡率的影响,并对天气、呼吸道流行病以及爱尔兰其他地区的死亡率进行了调整。
煤炭销售禁令实施后,都柏林的平均黑烟浓度下降了35.6毫克/立方米(70%)。调整后的非创伤性死亡率下降了5.7%(95%置信区间4%-7%,p<0.0001),呼吸道疾病死亡率下降了15.5%(12%-19%,p<0.0001),心血管疾病死亡率下降了10.3%(8%-13%,p<0.0001)。呼吸道和心血管标准化死亡率随着煤炭销售禁令的实施而下降。禁令实施后,都柏林每年呼吸道疾病死亡人数减少约116例,心血管疾病死亡人数减少约243例。
都柏林呼吸道和心血管疾病死亡率的下降表明,控制颗粒物空气污染可大幅降低每日死亡人数。死亡率降低带来的净效益大于先前时间序列研究结果的预测。