Mantovani Alberto, Schioppa Tiziana, Biswas Subhra K, Marchesi Federica, Allavena Paola, Sica Antonio
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Tumori. 2003 Sep-Oct;89(5):459-68. doi: 10.1177/030089160308900501.
Environmental signals polarize mononuclear phagocytes which can express different functional programmes. Fully polarized type I and type II (or alternatively activated) macrophages are the extremes of a continuum of functional states. Tumor-derived and T cell-derived cytokines stimulate tumor associated macrophages (TAM) to acquire a polarized type II phenotype. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumor growth and progression.
环境信号使单核吞噬细胞极化，这些细胞可表达不同的功能程序。完全极化的I型和II型（或替代性活化）巨噬细胞是一系列功能状态的两个极端。肿瘤衍生的细胞因子和T细胞衍生的细胞因子刺激肿瘤相关巨噬细胞（TAM）获得极化的II型表型。这些功能极化的细胞，以及肿瘤中存在的取向相似或未成熟的树突状细胞，在颠覆适应性免疫以及促进肿瘤生长和进展的炎症回路中起关键作用。
