Yamada Hideto, Furuta Itsuko, Kato Emi H, Kataoka Soromon, Usuki Yasuteru, Kobashi Gen, Sata Fumihiro, Kishi Reiko, Fujimoto Seiichiro
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku N15 W7, Sapporo 060-8638, Japan.
Reprod Toxicol. 2002 Nov-Dec;16(6):735-9. doi: 10.1016/s0890-6238(02)00051-5.
To assess human exposure to bisphenol A (BPA) over a 10-year period, BPA concentrations in maternal serum (MS) and amniotic fluid (AF) obtained at early second trimester were determined. ELISA was used to measure BPA in 200 MS/AF pairs in women carrying fetuses with normal karyotypes (Group I) and in 48 pairs with abnormal karyotypes (Group II). In Group I, BPA concentrations in AF (median: 0.26 ng/ml) were lower (P<0.01) than in MS (2.24 ng/ml). Over a 10-year period, yearly BPA concentrations in MS decreased from 5.62 to 0.99 ng/ml (P<0.001). Eight of the Group I AF samples had relatively high concentrations of BPA (2.80-5.62 ng/ml). In Group II, BPA concentrations in AF (0 ng/ml) were lower (P<0.01) than in MS (2.97 ng/ml). MS BPA concentrations in Group II were higher (P<0.01) than in Group I.
为评估10年间人体双酚A（BPA）的暴露情况，我们测定了孕中期早期获取的母血（MS）和羊水（AF）中的BPA浓度。采用酶联免疫吸附测定法（ELISA）检测了200对胎儿核型正常孕妇（I组）和48对胎儿核型异常孕妇（II组）的母血/羊水样本中的BPA。在I组中，羊水中的BPA浓度（中位数：0.26 ng/ml）低于母血（2.24 ng/ml）（P<0.01）。在10年期间，母血中BPA的年度浓度从5.62降至0.99 ng/ml（P<0.001）。I组中有8份羊水样本的BPA浓度相对较高（2.80 - 5.62 ng/ml）。在II组中，羊水中的BPA浓度（0 ng/ml）低于母血（2.97 ng/ml）（P<0.01）。II组母血中的BPA浓度高于I组（P<0.01）。
