School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA.
Environ Int. 2020 Mar;136:105407. doi: 10.1016/j.envint.2019.105407. Epub 2020 Jan 16.
Bisphenol A (BPA) and its alternatives are suspected endocrine disruptors. However, prenatal exposure and transplacental transfer of bisphenols (BPs is still limited. Therefore, BPA and its six alternatives in maternal serum (MS), maternal urine (MU), cord serum (CS), and amniotic fluid (AF) samples collected from 106 maternal-fetal pairs in an e-waste dismantling site in Southern China were determined. Bisphenol AF (BPAF) and bisphenol S (BPS) were the dominant BPA alternatives observed in MS and CS, and the geometric mean (GM) concentration of BPAF (0.013 ng/mL in MS, 0.097 ng/mL in CS) and BPS (0.01 ng/mL in MS, 0.03 ng/mL in CS) in MS and CS was lower than that of BPA (0.5 ng/mL in MS, 1.2 ng/mL in CS). The ratios of BPA concentrations between MU and MS (MU:MS ratio) were over three times higher than those of AF and CS (AF:CS ratio), thereby suggesting low biotransformation/metabolism of BPA in fetuses. The placental transfer rates of BPs (i.e., CS:MS ratio) were compound-specific (BPAF 3.26, BPA 1.94, BPS 1.11). Results suggest that BPA and its alternatives can pass through the placental barrier. The placental transfer rates of BPs are positively related to molecular weight or log K values. This finding indicates that an active transport is responsible for the placental transfer of BPs.
双酚 A（BPA）及其替代品被怀疑是内分泌干扰物。然而，双酚（BP）在产前的暴露和经胎盘转移仍有限。因此，在中国南方一个电子废物拆解现场的 106 对母婴对中，测定了母体血清（MS）、母体尿液（MU）、脐血清（CS）和羊水（AF）样本中双酚 AF（BPAF）和双酚 S（BPS）的含量。BPAF 和 BPS 是 MS 和 CS 中观察到的主要 BPA 替代品，BPAF（MS 中的 GM 浓度为 0.013ng/mL，CS 中的 GM 浓度为 0.097ng/mL）和 BPS（MS 中的 GM 浓度为 0.01ng/mL，CS 中的 GM 浓度为 0.03ng/mL）的 GM 浓度均低于 BPA（MS 中的 GM 浓度为 0.5ng/mL，CS 中的 GM 浓度为 1.2ng/mL）。MU 与 MS 中 BPA 浓度的比值（MU:MS 比值）高于 AF 和 CS 中 BPA 浓度的比值（AF:CS 比值），这表明胎儿对 BPA 的生物转化/代谢较低。BP 的胎盘转移率（即 CS:MS 比值）是化合物特异性的（BPAF 为 3.26，BPA 为 1.94，BPS 为 1.11）。结果表明，BPA 及其替代品可以穿过胎盘屏障。BP 的胎盘转移率与分子量或 logK 值呈正相关。这一发现表明，主动转运是 BP 胎盘转移的原因。
