Aris Aziz
Department of Obstetrics and Gynecology, Clinical Research Centre of Sherbrooke University Hospital Centre, Sherbrooke, Quebec, Canada.
Reprod Toxicol. 2014 Jun;45:8-13. doi: 10.1016/j.reprotox.2013.12.006. Epub 2013 Dec 28.
We determined bisphenol A (BPA) concentrations of 61 pregnant women (PW), their fetuses and 26 nonpregnant women (NPW) in Eastern Townships of Canada; and evaluated potential correlations between maternal and fetal blood, and between peripheral blood and peritoneal fluid. In PW, BPA levels were ranged from non-detected to 4.46ng/ml and from non-detected to 4.60ng/ml for maternal and fetal serum, respectively. In NPW, BPA levels were ranged from 1.30 to 8.17ng/ml and from 0.19 to 13.45ng/ml for serum and peritoneal fluid, respectively. Positive correlation was found between maternal and fetal serum, and between serum and peritoneal fluid. In conclusion, our findings highlight a continuous distribution of BPA between the mother and its fetus and reveal a role of pregnancy in underestimating the actual levels of blood BPA. Our study also provides a temporal-spatial reference on BPA exposure, which is a useful tool in monitoring, comparing and correcting.
我们测定了加拿大东部乡镇61名孕妇及其胎儿以及26名非孕妇的双酚A（BPA）浓度；并评估了母体与胎儿血液之间以及外周血与腹腔液之间的潜在相关性。在孕妇中，母体血清和胎儿血清中的BPA水平分别为未检测到至4.46纳克/毫升和未检测到至4.60纳克/毫升。在非孕妇中，血清和腹腔液中的BPA水平分别为1.30至8.17纳克/毫升和0.19至13.45纳克/毫升。在母体与胎儿血清之间以及血清与腹腔液之间发现了正相关。总之，我们的研究结果突出了双酚A在母体与其胎儿之间的连续分布，并揭示了怀孕在低估血液中双酚A实际水平方面的作用。我们的研究还提供了双酚A暴露的时空参考，这是监测、比较和校正中的一个有用工具。
