Vodolazhskaya M G, Beier E V
Department of Physiology, Stavropol' State University, Russia.
Neurosci Behav Physiol. 2002 Sep-Oct;32(5):485-93. doi: 10.1023/a:1019803521623.
Bilateral electrolytic lesioning of the striatum led to a delay in the acquisition of a conditioned reflex to time, along with an anxiogenic effect and disturbances to the normal relationship between the level of anxiety and chronometric ability. These changes progressed with increases in the size of the destruction zone in the striatum. Combined surgery consisting of lesions to the striatum and hippocampus, like hippocampectomy alone, completely eliminated the ability to count time regardless of the size of brain lesions. The anxiogenic effect was greater in animaLs with combined procedures. Thus, the striatum and hippocampus are involved to different extents in the mechanism of internal time counting. The two structures function synergistically.
双侧纹状体电解损伤导致对时间的条件反射习得延迟，同时产生致焦虑效应，并扰乱焦虑水平与计时能力之间的正常关系。这些变化随着纹状体破坏区域大小的增加而进展。由纹状体和海马体损伤组成的联合手术，与单独的海马切除术一样，无论脑损伤的大小如何，都完全消除了计时能力。联合手术的动物的致焦虑效应更大。因此，纹状体和海马体在内部计时机制中参与程度不同。这两个结构协同发挥作用。
