Tympner K D, Ewert U, Neuhaus F
Klin Padiatr. 1975 Nov;187(6):524-9.
In 496 sera of healthy children(cord blood, newborn infants, children up to 10 years of age) complement (C'3) was determined quantitatively by single radial immunodiffusion technique. Higher values are found in cord blood as compared to newborns during the first days of life. Adult levels are reached in infants aged 12 to 36 months. Complement is produced in excess. Normal concentrations do not necessarily exclude a pathologic situation. Abnormally high or low levels of complement (C'3) in the serum may point at pathologic processes. However, single determinations are of pathognomonic value only when low concentrations are found. Age dependency of C'3-levels in children has to be kept in mind when used for diagnosis.
采用单向免疫扩散技术对496份健康儿童（脐血、新生儿、10岁以下儿童）血清中的补体（C'3）进行了定量测定。与出生后最初几天的新生儿相比，脐血中的补体值更高。12至36个月大的婴儿达到成人水平。补体产生过量。正常浓度并不一定排除病理情况。血清中补体（C'3）水平异常高或低可能提示病理过程。然而，只有在发现低浓度时，单次测定才有诊断价值。在用于诊断时，必须牢记儿童C'3水平的年龄依赖性。
