胶质瘤小鼠模型的磁共振成像显示出与人类的相似性，可用于识别用于临床前试验的小鼠。
MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials.
作者信息
Koutcher Jason A, Hu Xiaoyi, Xu Su, Gade Terence P F, Leeds Norman, Zhou Xiaohong Joe, Zagzag David, Holland Eric C
机构信息
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
出版信息
Neoplasia. 2002 Nov-Dec;4(6):480-5. doi: 10.1038/sj.neo.7900269.
Abstract
Magnetic resonance imaging (MRI) has been utilized for screening and detecting brain tumors in mice based upon their imaging characteristics appearance and their pattern of enhancement. Imaging of these tumors reveals many similarities to those observed in humans with identical pathology. Specifically, high-grade murine gliomas have histologic characteristics of glioblastoma multiforme (GBM) with contrast enhancement after intravenous administration of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), implying disruption of the blood-brain barrier in these tumors. In contrast, low-grade murine oligodendrogliomas do not reveal contrast enhancement, similar to human tumors. MRI can be used to identify mice with brain neoplasms as inclusion criteria in preclinical trials.
摘要
磁共振成像（MRI）已被用于根据小鼠脑肿瘤的成像特征外观及其强化模式来筛查和检测脑肿瘤。这些肿瘤的成像显示出与具有相同病理学特征的人类脑肿瘤有许多相似之处。具体而言，高级别小鼠胶质瘤具有多形性胶质母细胞瘤（GBM）的组织学特征，静脉注射钆喷酸葡胺（Gd-DTPA）后有对比增强，这意味着这些肿瘤的血脑屏障遭到破坏。相比之下，低级别小鼠少突胶质细胞瘤与人类肿瘤相似，没有显示出对比增强。MRI可用于识别患有脑肿瘤的小鼠，作为临床试验的纳入标准。
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