Holguín Africa, Soriano Vincent
Service of Infectious Diseases, Instituto de Salud Carlos III, Madrid, Spain.
HIV Clin Trials. 2002 Sep-Oct;3(5):403-11. doi: 10.1310/7bwp-0x7f-nxna-qrnp.
Naturally occurring polymorphisms at positions involved in resistance to antiretroviral agents are frequently seen in HIV-1 non-B subtypes. Although they do not seem to affect significantly the susceptibility to antiretroviral drugs in vitro, they may facilitate the selection of different pathways and/or a more rapid emergence of drug resistance and treatment failure under not fully suppressive treatment regimens.
在抗逆转录病毒药物耐药相关位点出现的自然多态性在HIV-1非B亚型中很常见。尽管它们在体外似乎对对抗逆转录病毒药物的敏感性没有显著影响，但在不完全抑制的治疗方案下，它们可能会促进不同耐药途径的选择和/或耐药性更快出现以及治疗失败。
