Vega Francisco, Orduz Rocio, Medeiros L Jeffrey
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA.
Pathology. 2002 Oct;34(5):397-409. doi: 10.1080/0031302021000009306.
The discovery that non-Hodgkin's lymphomas are monoclonal and that recurrent chromosomal translocations are involved in their pathogenesis has greatly revolutionised their diagnosis and improved our understanding of these diseases. In the last decades, many genes deregulated by such recurrent chromosomal translocations have been identified. However, we have also learned that these genetic alterations are apparently insufficient, in themselves, to cause neoplastic cell transformation and that more complex genetic events must be involved. This review examines the involved genes in chromosomal translocations and current evidence and postulated mechanisms for their role in the pathogenesis of non-Hodgkin's lymphomas.
非霍奇金淋巴瘤是单克隆性的，且复发性染色体易位参与其发病机制，这一发现极大地变革了其诊断方法，并增进了我们对这些疾病的理解。在过去几十年里，许多因此类复发性染色体易位而失调的基因已被鉴定出来。然而，我们也认识到，这些基因改变本身显然不足以导致肿瘤细胞转化，必然涉及更复杂的基因事件。这篇综述探讨了染色体易位中涉及的基因，以及目前关于它们在非霍奇金淋巴瘤发病机制中作用的证据和推测机制。
