Chung Shin Ho, Kuyucak Serdar
Protein Dynamics Unit, Department of Physics, Faculty of Sciences, Australian National University, Canberra, Australia.
Biochim Biophys Acta. 2002 Oct 11;1565(2):267-86. doi: 10.1016/s0005-2736(02)00574-6.
The field of ion channels has entered into a rapid phase of development in the last few years, partly due to the breakthroughs in determination of the crystal structures of membrane proteins and advances in computer simulations of biomolecules. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplified accounts of the competing permeation theories and then discuss their application to the potassium, gramicidin A and calcium channels.
在过去几年里，离子通道领域进入了快速发展阶段，部分原因是膜蛋白晶体结构测定方面的突破以及生物分子计算机模拟技术的进步。这些进展最终实现了将通道功能与其潜在分子结构联系起来这一长期以来梦寐以求的目标。在此，我们简要介绍相互竞争的渗透理论，然后讨论它们在钾通道、短杆菌肽A通道和钙通道中的应用。
