Hampton Diana E, Adesina Adekunle, Chodosh James
Molecular Pathogenesis of Eye Infection Research Center, Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
Cornea. 2002 Nov;21(8):831-3. doi: 10.1097/00003226-200211000-00021.
To describe a patient with conjunctivitis.
Case report and review of the literature.
A 34-year-old cattle farmer with no history of trauma developed gradual onset of an inflamed bulbar conjunctival mass associated with ipsilateral preauricular lymphadenopathy. Excisional biopsy of the conjunctival mass and subsequent histopathologic examination revealed suppurative granulomatous inflammation and small budding yeasts. Electron microscopy confirmed the presence of small intracellular and extracellular yeast organisms. Cultures grew the dimorphic fungi Treatment with oral itraconazole and topical fluconazole resulted in complete resolution of the infection.
characteristically infects the skin and regional lymphatics after penetrating trauma, but atraumatic infection of pulmonary mucosal surfaces can occur upon inhalation of the fungal spores. Our case report suggests that atraumatic exposure to may be sufficient to establish conjunctival infection.
描述一例结膜炎患者。
病例报告及文献复习。
一名34岁的养牛农民，无外伤史，逐渐出现球结膜肿物伴同侧耳前淋巴结肿大。对结膜肿物进行切除活检及后续组织病理学检查显示为化脓性肉芽肿性炎症和小的芽生酵母。电子显微镜证实存在小的细胞内和细胞外酵母样生物体。培养物培养出双相真菌。口服伊曲康唑和局部应用氟康唑治疗使感染完全消退。
通常在穿透性外伤后感染皮肤和区域淋巴管，但吸入真菌孢子后可发生肺黏膜表面的无创伤性感染。我们的病例报告提示，无创伤性接触可能足以导致结膜感染。
