Tawil Rabi, Griggs Robert C
Department of Neurology, University of Rochester, Rochester, New York 14642, USA.
Curr Opin Rheumatol. 2002 Nov;14(6):653-7. doi: 10.1097/00002281-200211000-00004.
Inclusion body myositis (IBM) is an inflammatory myopathy with distinctive clinicopathologic features. The etiology of IBM remains elusive. The immune-mediated basis for this disease has been challenged by evidence implicating a number of divergent etiologic factors. These factors include mitochondrial deletions, nitric oxide induced oxidative stress, myonuclear breakdown, and abnormal accumulation within muscle fibers of brain-specific Alzheimer type proteins. The treatment of IBM with conventional immunosuppressive agents has been disappointing. Therapeutic approaches currently under study or consideration are beta-interferon and synthetic anabolic hormones.
包涵体肌炎（IBM）是一种具有独特临床病理特征的炎性肌病。IBM的病因仍不清楚。该疾病的免疫介导基础受到了一系列不同病因因素证据的挑战。这些因素包括线粒体缺失、一氧化氮诱导的氧化应激、肌核崩解以及脑特异性阿尔茨海默型蛋白在肌纤维内的异常积聚。用传统免疫抑制剂治疗IBM一直令人失望。目前正在研究或考虑的治疗方法是β干扰素和合成同化激素。
