Weiner Paltiel, Magadle Rasmi, Beckerman Marinella, Berar-Yanay Noa
Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel.
Can Respir J. 2002 Sep-Oct;9(5):307-12. doi: 10.1155/2002/746808.
It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is related to the activity and strength of the inspiratory muscles, and influences the use of 'as needed' beta2-agonists.
To investigate the relationship among the increase in inspiratory muscle strength after specific inspiratory muscle training, beta2-agonist consumption and the POD in patients with persistent, mild to moderate asthma.
Inspiratory muscle strength, daily beta2-agonist consumption and the POD were measured in 30 patients with mild to moderate asthma. Patients were then randomly assigned to two groups: one group received specific inspiratory muscle training until an increase of more than 20 cm H2O was reached, and one group was a control group and received sham training. Inspiratory muscle strength, the POD and daily beta2-agonist consumption were assessed during and after the training period.
There was no good correlation between the baseline maximal inspiratory pressure and the POD, or between the baseline maximal inspiratory pressure and the mean daily beta2-agonist consumption. However, there was a significant correlation between the POD and the mean daily beta2-agonist consumption. The increase in inspiratory muscle strength after the inspiratory muscle training was closely correlated with the decrease in the POD (P<0.001) and the decrease in beta2-agonist consumption (P<0.001).
The present study shows that, in patients with mild to moderate, persistent asthma, there is a correlation between the POD and the mean daily beta2-agonist consumption. When the inspiratory muscles are strengthened, there is a significant decrease in the POD and in beta2-agonist consumption.
有充分文献记载，患者主观报告的呼吸困难感知（POD）与吸气肌的活动和力量相关，并影响“按需”使用β2激动剂。
探讨特定吸气肌训练后吸气肌力量增加、β2激动剂使用量与持续性轻度至中度哮喘患者的POD之间的关系。
对30例轻度至中度哮喘患者测量吸气肌力量、每日β2激动剂使用量和POD。然后将患者随机分为两组：一组接受特定吸气肌训练，直至吸气肌力量增加超过20 cm H2O，另一组为对照组，接受假训练。在训练期间及训练后评估吸气肌力量、POD和每日β2激动剂使用量。
基线最大吸气压与POD之间，或基线最大吸气压与每日平均β2激动剂使用量之间均无良好相关性。然而，POD与每日平均β2激动剂使用量之间存在显著相关性。吸气肌训练后吸气肌力量的增加与POD的降低（P<0.001）和β2激动剂使用量的降低（P<0.001）密切相关。
本研究表明，在轻度至中度持续性哮喘患者中，POD与每日平均β2激动剂使用量之间存在相关性。当吸气肌力量增强时，POD和β2激动剂使用量均显著降低。
