Hauck Christof R
Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, Germany.
Med Microbiol Immunol. 2002 Oct;191(2):55-62. doi: 10.1007/s00430-002-0119-0. Epub 2002 Sep 11.
Cell adhesion receptors play an essential role in multicellular organisms by mediating the direct association of cells with each other and with proteins of the extracellular matrix. Members of different protein families such as integrins, cadherins, immunoglobulin superfamily cell adhesion molecules (IgCAMs), selectins, and syndecans not only support the structural integrity of cells and tissues, but also contribute to the transduction of signals. Interestingly, several of these molecules are exploited by bacterial pathogens to establish tight contact with eukaryotic cells. Using the example of integrins, cadherins, and IgCAMs, this review illustrates the signaling capacity of cell adhesion receptors and highlights a number of bacterial adhesins that are known to engage these receptors. Where applicable, the role of the receptor-adhesin interaction in the course of the infection is discussed.
细胞黏附受体在多细胞生物中发挥着至关重要的作用，它介导细胞彼此之间以及细胞与细胞外基质蛋白的直接结合。不同蛋白质家族的成员，如整合素、钙黏蛋白、免疫球蛋白超家族细胞黏附分子（IgCAMs）、选择素和蛋白聚糖，不仅支持细胞和组织的结构完整性，还参与信号转导。有趣的是，一些细菌病原体利用这些分子中的几种与真核细胞建立紧密接触。本文以整合素、钙黏蛋白和IgCAMs为例，阐述了细胞黏附受体的信号传导能力，并重点介绍了一些已知能与这些受体结合的细菌黏附素。在适用的情况下，还讨论了受体 - 黏附素相互作用在感染过程中的作用。
