Boyle Erin C, Finlay B Brett
Department of Microbiology and Immunology, Biotechnology Laboratory, Wesbrook Building, Room 237, 6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Curr Opin Cell Biol. 2003 Oct;15(5):633-9. doi: 10.1016/s0955-0674(03)00099-1.
Cell adhesion molecules, such as integrins, cadherins, the immunoglobulin superfamily of cell adhesion molecules and selectins, play important structural roles and are involved in various signal transduction processes. As an initial step in the infectious process, many bacterial pathogens adhere to cell adhesion molecules as a means of exploiting the underlying signaling pathways, entering into host cells or establishing extracellular persistence. Often, bacteria are able to bind to cell adhesion molecules by mimicking or acting in place of host cell receptors or their ligands. Recent studies have contributed to our understanding of bacterial adherence mechanisms and the consequences of receptor engagement; they have also highlighted alternative functions of cell adhesion molecules.
细胞黏附分子，如整合素、钙黏蛋白、细胞黏附分子免疫球蛋白超家族和选择素，发挥着重要的结构作用，并参与各种信号转导过程。作为感染过程的第一步，许多细菌病原体通过利用潜在的信号通路、进入宿主细胞或建立细胞外持续性，黏附于细胞黏附分子。通常，细菌能够通过模仿宿主细胞受体或其配体或替代其作用来结合细胞黏附分子。最近的研究有助于我们理解细菌黏附机制以及受体结合的后果；这些研究还突出了细胞黏附分子的其他功能。
