Hauck Christof R, Agerer Franziska, Muenzner Petra, Schmitter Tim
Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany.
Eur J Cell Biol. 2006 Apr;85(3-4):235-42. doi: 10.1016/j.ejcb.2005.08.002. Epub 2005 Sep 12.
A large number of bacterial pathogens targets cell adhesion molecules to establish an intimate contact with host cells and tissues. Members of the integrin, cadherin and immunoglobulin-related cell adhesion molecule (IgCAM) families are frequently recognized by specific bacterial surface proteins. Binding can trigger bacterial internalization following cytoskeletal rearrangements that are initiated upon receptor clustering. Moreover, signals emanating from the occupied receptors can result in cellular responses such as gene expression events that influence the phenotype of the infected cell. This review will address recent advances in our understanding of bacterial engagement of cellular adhesion molecules by discussing the binding of integrins by Staphylococcus aureus as well as the exploitation of IgCAMs by pathogenic Neisseria species.
大量细菌病原体靶向细胞粘附分子，以与宿主细胞和组织建立紧密接触。整联蛋白、钙粘蛋白和免疫球蛋白相关细胞粘附分子（IgCAM）家族的成员经常被特定的细菌表面蛋白识别。结合可在受体聚集引发的细胞骨架重排后触发细菌内化。此外，占据的受体发出的信号可导致细胞反应，如影响受感染细胞表型的基因表达事件。本综述将通过讨论金黄色葡萄球菌对整联蛋白的结合以及致病性奈瑟菌属对IgCAMs的利用，阐述我们对细菌与细胞粘附分子相互作用的最新认识进展。
