Yachida Shinichi, Fukushima Noriyoshi, Kanai Yae, Nimura Satoshi, Shimada Kazuaki, Yamamoto Junji, Sakamoto Michiie
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
Jpn J Clin Oncol. 2002 Aug;32(8):315-7. doi: 10.1093/jjco/hyf066.
While metastasis to the pancreas is uncommon, it may occur from renal cell carcinomas (RCCs). We here present a case of pancreatic metastasis from RCC extending into the main pancreatic duct (MPD) in a 66-year-old Japanese man. The patient had a history of RCC treated with a radical nephrectomy 17 years previously and was found to have a mass approximately 2 cm in diameter in the body of the pancreas on radiological images. The patient was suspected of having pancreatic metastasis from RCC and underwent a distal pancreatectomy with splenectomy. Histologically, the tumor consisted of cells arranged in trabecular and alveolar structures with clear or eosinophilic granular cytoplasm, compatible with a metastatic RCC. The pancreatic tumor extended into the MPD with the stream of pancreatic juice. This condition is similar to RCC extension into the renal vein and the inferior vena cava. In conclusion, although extension into the MPD may be rare, such a growth pattern may be characteristic of metastases from RCCs.
虽然胰腺转移并不常见，但肾细胞癌（RCC）可能会发生这种情况。我们在此报告一例66岁日本男性，其肾细胞癌转移至胰腺并延伸至主胰管（MPD）。该患者17年前曾因肾细胞癌接受根治性肾切除术，影像学检查发现胰腺体部有一个直径约2 cm的肿块。患者被怀疑患有肾细胞癌胰腺转移，并接受了远端胰腺切除术加脾切除术。组织学上，肿瘤由排列成小梁状和腺泡状结构的细胞组成，细胞质清晰或呈嗜酸性颗粒状，符合转移性肾细胞癌。胰腺肿瘤随胰液流延伸至主胰管。这种情况类似于肾细胞癌延伸至肾静脉和下腔静脉。总之，虽然延伸至主胰管可能很少见，但这种生长模式可能是肾细胞癌转移的特征。
