人类丝虫病血清中的抗体与乙胺嗪发生反应。
Antibodies in human filariasis sera react with diethylcarbamazine.
作者信息
Ravindran B, Satapathy A K, Hussain T, Pattnaik A M
出版信息
Clin Exp Immunol. 1989 Nov;78(2):219-23.
Abstract
We demonstrate by an ELISA the presence of antibodies in human filarial sera that react with diethylcarbamazine (DEC); they appear to be primarily filarial antibodies cross-reacting with DEC skeleton, since affinity-purified DEC antibodies strongly react with Wuchereria bancrofti microfilariae. These observations indicate a possible antigenic mimicry between the drug and some parasite component.
摘要
我们通过酶联免疫吸附测定（ELISA）证明，人类丝虫病血清中存在与乙胺嗪（DEC）发生反应的抗体；这些抗体似乎主要是与DEC骨架发生交叉反应的丝虫抗体，因为亲和纯化的DEC抗体能与班氏吴策线虫微丝蚴强烈反应。这些观察结果表明该药物与某些寄生虫成分之间可能存在抗原模拟。
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本文引用的文献
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Immunol Lett. 1988 Jan;17(1):7-11. doi: 10.1016/0165-2478(88)90094-6.
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