Pancré V, Cesbron J Y, Auriault C, Joseph M, Chandenier J, Capron A
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.
Int Arch Allergy Appl Immunol. 1988;85(4):483-6. doi: 10.1159/000234556.
Platelets isolated from patients infected with filariasis were cytotoxic for microfilariae in vitro. Moreover, platelets from normal donors acquired killing properties in the presence of serum from infected individuals. The humoral factor involved in this cytotoxic process was shown to be IgE. This IgE-dependent cytotoxicity of platelets was strongly inhibited by antigen-stimulated T lymphocyte supernatants from filarial patients.
从感染丝虫病的患者中分离出的血小板在体外对微丝蚴具有细胞毒性。此外，在存在来自感染个体血清的情况下，正常供体的血小板获得了杀伤特性。参与这一细胞毒性过程的体液因子被证明是IgE。来自丝虫病患者的抗原刺激的T淋巴细胞上清液强烈抑制血小板的这种IgE依赖性细胞毒性。
