秋水仙碱对迟发型超敏反应的抑制作用。II. 秋水仙碱抑制干扰素-γ诱导的肠道上皮细胞系上HLA-DR的表达。
Inhibition of delayed hypersensitivity reactions by colchicine. II. Colchicine inhibits interferon-gamma induced expression of HLA-DR on gut epithelial cell line.
作者信息
Mekori Y A, Chowers Y, Ducker I, Klajman A
机构信息
Allergy-Immunology Unit, Meir Hospital, Kfar Saba, Israel.
出版信息
Clin Exp Immunol. 1989 Nov;78(2):230-2.
Abstract
The effects of colchicine and vinblastine on interferon-gamma (IFN-gamma) induced expression of HLA-DR antigens on the HT-29 colonic carcinoma cell line was investigated in vitro. Both drugs prevented the expression of HLA-DR only if applied before or together with IFN-gamma. Methotrexate, an antimitotic drug, failed to inhibit DR expression by these cells. Colchicine and vinblastine, but not methotrexate, act on the cellular microtubules, interfering with the transport of proteins from the protoplasm to the cell surface and thus preventing the appearance of HLA-DR antigens. The reported findings may explain the role of colchicine in preventing delayed hypersensitivity reactions.
摘要
在体外研究了秋水仙碱和长春碱对干扰素-γ（IFN-γ）诱导的HT-29结肠癌细胞系上HLA-DR抗原表达的影响。仅在与IFN-γ同时应用或在其之前应用时，这两种药物才会阻止HLA-DR的表达。抗有丝分裂药物甲氨蝶呤未能抑制这些细胞的DR表达。秋水仙碱和长春碱作用于细胞微管，而甲氨蝶呤则不然，它们干扰蛋白质从原生质向细胞表面的转运，从而阻止HLA-DR抗原的出现。所报道的研究结果可能解释了秋水仙碱在预防迟发型超敏反应中的作用。
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