秋水仙碱对人体志愿者多形核白细胞趋化性的影响。
Effect of colchicine on polymorphonuclear leucocyte chemotaxis in human volunteers.
作者信息
Ehrenfeld M, Levy M, Bar Eli M, Gallily R, Eliakim M
出版信息
Br J Clin Pharmacol. 1980 Sep;10(3):297-300. doi: 10.1111/j.1365-2125.1980.tb01759.x.
Abstract
1 The effect of colchicine on polymorphonuclear leucocyte chemotaxis was assessed in eight healthy volunteers. Four of them received 1.0 mg colchicine and the other four received placebo daily for 8 successive days. 2 Chemotaxis decreased significantly within 24 h of the ingestion of colchicine; the values remained low throughout the 8 days of treatment and returned to normal within 48 h of cessation of medication. 3 There were no significant changes in the placebo treated subjects.
摘要
在八名健康志愿者身上评估了秋水仙碱对多形核白细胞趋化性的影响。其中四人每天服用1.0毫克秋水仙碱，另外四人连续八天每天服用安慰剂。
服用秋水仙碱后24小时内趋化性显著降低；在整个8天的治疗过程中该值一直较低，停药后48小时内恢复正常。
接受安慰剂治疗的受试者没有显著变化。
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