Ozçelik D, Toplan S, Ozdemir S, Akyolcu M C
Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
Biol Trace Elem Res. 2002 Oct;89(1):35-42. doi: 10.1385/BTER:89:1:35.
Copper plays an important role in the structure and function of metalloproteins and in the absorption of iron. The present study deals with the effects of excessive copper intake on hematological and hemorheological parameters. Drinking water containing 250 microg/mL copper for a period of 9 wk, Wistar albino rats showed increased erythrocyte count, blood viscosity, and hematocrit values (p<0.05) and lower hemoglobin (p<0.05) than controls fed a normal diet. The two groups also had differences in the erythrocyte deformability index. The results suggest that excessive copper intake results in hematological and hemorheological changes affecting both the protein content of the erythrocyte membrane and heme synthesis.
铜在金属蛋白的结构和功能以及铁的吸收过程中发挥着重要作用。本研究探讨了过量摄入铜对血液学和血液流变学参数的影响。给Wistar白化大鼠饮用含250微克/毫升铜的水，持续9周，与喂食正常饮食的对照组相比，这些大鼠的红细胞计数、血液粘度和血细胞比容值均有所增加（p<0.05），而血红蛋白含量则较低（p<0.05）。两组在红细胞变形性指数方面也存在差异。结果表明，过量摄入铜会导致血液学和血液流变学变化，这会影响红细胞膜的蛋白质含量和血红素合成。
