Kopp Daniel A, Lippard Stephen J
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 18-498, Cambridge 02139, USA.
Curr Opin Chem Biol. 2002 Oct;6(5):568-76. doi: 10.1016/s1367-5931(02)00366-6.
The mechanisms by which soluble methane monooxygenase uses dioxygen to convert methane selectively to methanol have come into sharp focus. Diverse techniques have clarified subtle details about each step in the reaction, from binding and activating dioxygen, to hydroxylation of alkanes and other substrates, to the electron transfer events required to complete the catalytic cycle.
可溶性甲烷单加氧酶利用双加氧将甲烷选择性转化为甲醇的机制已成为研究热点。多种技术已阐明了该反应中每个步骤的细微细节，从双加氧的结合和活化，到烷烃及其他底物的羟基化，再到完成催化循环所需的电子转移过程。
