克拉维酸生物合成中的新反应。
New reactions in clavulanic acid biosynthesis.
作者信息
Townsend Craig A
机构信息
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.
出版信息
Curr Opin Chem Biol. 2002 Oct;6(5):583-9. doi: 10.1016/s1367-5931(02)00392-7.
Abstract
Clavulanic acid is only a modestly effective antibiotic against bacterial infections in humans, but a potent inhibitor/inactivator of beta-lactamase enzymes that confer bacterial resistance. The biosynthetic pathway to clavulanic acid is considerably more complex than that to the structurally related penicillins and cephalosporins and has revealed several interesting reactions.
摘要
棒酸对人类细菌感染只是一种效果一般的抗生素，但却是β-内酰胺酶的强效抑制剂/灭活剂，而β-内酰胺酶会导致细菌产生耐药性。棒酸的生物合成途径比结构相关的青霉素和头孢菌素的生物合成途径要复杂得多，并且已经揭示了几种有趣的反应。
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